ceesdekker No Further a Mystery
ceesdekker No Further a Mystery
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Nanotechnology provides A variety of chances to add to biology. In this article I'll existing illustrations in which nanofabrication – the chance to make confined constructions with dimensions at will – is utilised to look at the biophysics of solitary molecules and cells. I will current some examples from our lab:
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2007, to start with actual-time detection of strand exchange in homologous recombination by RecA; discovery of the small persistence length of ends of microtubules; and solved the system of biosensing with carbon nanotubes
2015, discovery that condensin is actually a highly adaptable protein construction; and first detection of DNA knots working with nanopores
Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim of your pore is highlighted in purple, along with a 3D rendering of your motion of the DNA rod is exhibited.
We shape bacteria into forms that deviate from their purely natural phenotype. Precisely, I'll demonstrate our capability to shape Stay E. coli micro organism into novel shapes such as rectangles, squares, triangles and circles.
2000, discovery that nanotubes can have extraordinary substantial current densities; settled the controversial challenge of Digital transport by way of DNA molecules by measurements of insulating actions at the single molecule degree; and demonstration of the AFM technique for single-molecule manipulation of nanotubes
In 1993, being a youthful and eager associate professor at Delft University of Know-how, I'd at first centered the investigate efforts of my group on measuring the electrical conductance of an individual conducting-polymer molecule. In just two many years, we had designed a tool in which just one wire of a phthalocyaninepolysiloxane polymer was linked involving two intently spaced metallic nanoelectrodes.
There was 1 difficulty however — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up basically not such fantastic conductors, which was instead disappointing. We Hence broadened our check out to try to discover far more promising molecules.
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for the new Luttinger description of interacting electrons in nanotubes
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It had been a very intriguing time, all through which I obtained a great cees dekker deal of aid from Delft University of Technological innovation, where by I was a professor at time, and I started off several collaborations with molecular biologists. That helped me find out quite a bit.’